OXIDANT STRESS LEADS TO TRANSCRIPTIONAL ACTIVATION OF THE HUMAN HEME OXYGENASE GENE IN CULTURED SKIN FIBROBLASTS

被引：206

作者：

KEYSE, SM ^{[1
]}

APPLEGATE, LA ^{[1
]}

TROMVOUKIS, Y ^{[1
]}

TYRRELL, RM ^{[1
]}

机构：

[1] SWISS INST EXPTL CANC RES,CH-1066 EPALINGES,SWITZERLAND

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1990年 / 10卷 / 09期

关键词：

D O I：

10.1128/MCB.10.9.4967

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Treatment of cultured human skin fibroblasts with near-UV radiation, hydrogen peroxide, and sodium arsenite induces accumulation of heme oxygenase mRNA and protein. In this study, these treatments led to a dramatic increase in the rate of RNA transcription from the heme oxygenase gene but had no effect om mRNA stability. Transcriptional activation, therefore, appears to be the major mechanism of stimulation of expression of this gene by either oxidative stress or sulfydryl reagents.

引用

页码：4967 / 4969

页数：3

共 19 条

[1]

ALAM J, 1989, J BIOL CHEM, V264, P6371

[2] POSITIVE CONTROL OF A REGULON FOR DEFENSES AGAINST OXIDATIVE STRESS AND SOME HEAT-SHOCK PROTEINS IN SALMONELLA-TYPHIMURIUM [J].

CHRISTMAN, MF ;

MORGAN, RW ;

JACOBSON, FS ;

AMES, BN .

CELL, 1985, 41 (03) :753-762

[3] INDUCIBLE REPAIR OF OXIDATIVE DNA DAMAGE IN ESCHERICHIA-COLI [J].

DEMPLE, B ;

HALBROOK, J .

NATURE, 1983, 304 (5925) :466-468

[4] TRANSCRIPTIONAL REGULATION OF HEMOGLOBIN SWITCHING IN CHICKEN EMBRYOS [J].

GROUDINE, M ;

PERETZ, M ;

WEINTRAUB, H .

MOLECULAR AND CELLULAR BIOLOGY, 1981, 1 (03) :281-288

[5] THE ANTIOXIDANT ACTIVITY OF HAPTOGLOBIN TOWARDS HEMOGLOBIN-STIMULATED LIPID-PEROXIDATION [J].

GUTTERIDGE, JMC .

BIOCHIMICA ET BIOPHYSICA ACTA, 1987, 917 (02) :219-223

[6] ANTIOXIDANT PROTECTION BY HEMOPEXIN OF HAEM-STIMULATED LIPID-PEROXIDATION [J].

GUTTERIDGE, JMC ;

SMITH, A .

BIOCHEMICAL JOURNAL, 1988, 256 (03) :861-865

[7]

ISHIZAWA S, 1983, J BIOL CHEM, V258, P4220

[8] INDUCTION OF THE HEME OXYGENASE GENE IN HUMAN SKIN FIBROBLASTS BY HYDROGEN-PEROXIDE AND UVA (365 NM) RADIATION - EVIDENCE FOR THE INVOLVEMENT OF THE HYDROXYL RADICAL [J].

KEYSE, SM ;

TYRRELL, RM .

CARCINOGENESIS, 1990, 11 (05) :787-791

[9] HEME OXYGENASE IS THE MAJOR 32-KDA STRESS PROTEIN-INDUCED IN HUMAN-SKIN FIBROBLASTS BY UVA RADIATION, HYDROGEN-PEROXIDE, AND SODIUM ARSENITE [J].

KEYSE, SM ;

TYRRELL, RM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (01) :99-103

[10]

KEYSE SM, 1987, J BIOL CHEM, V262, P14821

← 1 2 →