ANTIHYPERTENSIVE AND RENAL EFFECTS OF ENALAPRIL AND SLOW-RELEASE VERAPAMIL IN ESSENTIAL-HYPERTENSION - A DOUBLE-BLIND, RANDOMIZED STUDY

被引：5
|
作者：
FAGHER, B
HENNINGSEN, N
HULTHEN, L
KATZMAN, P
THULIN, T
机构：
[1] UNIV LUND, MALMO GEN HOSP, DEPT MED, S-21401 MALMO, SWEDEN
[2] UNIV LUND, MALMO GEN HOSP, DEPT ENDOCRINOL, S-21401 MALMO, SWEDEN
来源：
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1990年 / 39卷
关键词：
Enalapril; hypertension; renal function; verapamil;
D O I：
10.1007/BF01409207
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The renal, metabolic and antihypertensive effects of enalapril (E) and slow-release verapamil (V) were compared in a 2-month double-blind crossover trial in 22 patients with newly discovered essential hypertension. The glomerular filtration rate and renal vascular resistance were unaltered; renal blood flow was slightly decreased by V Serum Ca2+ increased and Na+ excretion declined after V. Serum lipids, glucose, and erythrocyte electrolytes were unchanged. Blood pressure (BP) was lower with E after half the maximum dosage compared with V but similar BP reductions were obtained after 2 months with the maximum dosage. © 1990 Springer-Verlag.
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页码：S41 / S43
页数：3
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