ANTIHYPERTENSIVE AND RENAL EFFECTS OF ENALAPRIL AND SLOW-RELEASE VERAPAMIL IN ESSENTIAL-HYPERTENSION - A DOUBLE-BLIND, RANDOMIZED STUDY

被引：5

作者：

FAGHER, B

HENNINGSEN, N

HULTHEN, L

KATZMAN, P

THULIN, T

机构：

[1] UNIV LUND, MALMO GEN HOSP, DEPT MED, S-21401 MALMO, SWEDEN

[2] UNIV LUND, MALMO GEN HOSP, DEPT ENDOCRINOL, S-21401 MALMO, SWEDEN

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1990年 / 39卷

关键词：

Enalapril; hypertension; renal function; verapamil;

D O I：

10.1007/BF01409207

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The renal, metabolic and antihypertensive effects of enalapril (E) and slow-release verapamil (V) were compared in a 2-month double-blind crossover trial in 22 patients with newly discovered essential hypertension. The glomerular filtration rate and renal vascular resistance were unaltered; renal blood flow was slightly decreased by V Serum Ca2+ increased and Na+ excretion declined after V. Serum lipids, glucose, and erythrocyte electrolytes were unchanged. Blood pressure (BP) was lower with E after half the maximum dosage compared with V but similar BP reductions were obtained after 2 months with the maximum dosage. © 1990 Springer-Verlag.

引用

页码：S41 / S43

页数：3