Review of checkpoint immunotherapy for the management of non-small cell lung cancer

被引：54

作者：

Raju, Shine ^{[1
]}

Joseph, Ranjit ^{[2
]}

Sehgal, Sameep ^{[3
]}

机构：

[1] Case Western Univ, Div Geriatr & Palliat Care, Cleveland, OH USA

[2] Univ N Carolina, Div Hematol & Oncol, Chapel Hill, NC USA

[3] Temple Univ, Lewis Katz Sch Med, Dept Thorac Med & Surg, 3401 N Broad St, Philadelphia, PA 19130 USA

来源：

IMMUNOTARGETS AND THERAPY | 2018年 / 7卷

关键词：

non-small cell lung cancer; PD-1; inhibitors; PD-L1; pembrolizumab; nivolumab; atezolizumab;

D O I：

10.2147/ITT.S125070

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Checkpoint immunotherapy uses highly selective humanized monoclonal antibodies against checkpoint signals such as programmed cell death receptor (PD-1) and programmed cell death ligand (PD-L1). By blocking these receptors and signals, the immune system can be reactivated to fight the tumor. Immunotherapy for advanced non-small cell lung cancer (NSCLC) has resulted in a new paradigm of treatment options resulting in improved survival and response rates and has a less severe yet unique toxicity profile when compared to chemotherapy. PD-1 inhibitors, nivolumab and pembrolizumab, and PD-L1 inhibitor, atezolizumab, are currently approved by regulatory authorities for the treatment of advanced NSCLC. This article provides a detailed review of these newer agents, their mechanism of action, side-effect profile, therapeutic indications and current evidence supporting their use in the management of NSCLC.

引用

页码：63 / 75

页数：13

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