Autoimmune-Related Retinopathy and Optic Neuropathy Accompanied by Anti-GAD Antibodies

被引：3

作者：

Almarzouqi, Sumayya J. ^{[1
]}

Morgan, Michael L. ^{[1
]}

Carvounis, Petros E. ^{[2
]}

Lee, Andrew G. ^{[1
,3
,4
,5
,6
,7
,8
]}

机构：

[1] Houston Methodist Hosp, Dept Ophthalmol, 6560 Fannin St,Scurlock 450, Houston, TX 77030 USA

[2] Baylor Coll Med, Houston, TX 77030 USA

[3] Weill Cornell Med Coll, Dept Ophthalmol, Houston, TX USA

[4] Weill Cornell Med Coll, Dept Neurol, Houston, TX USA

[5] Weill Cornell Med Coll, Dept Neurosurg, Houston, TX USA

[6] Univ Texas Med Branch, Dept Ophthalmol, Galveston, TX 77555 USA

[7] Univ Texas MD Anderson Canc Ctr, Dept Head & Neck Surg, Houston, TX 77030 USA

[8] Univ Iowa Hosp & Clin, Dept Ophthalmol, Iowa City, IA 52242 USA

来源：

NEURO-OPHTHALMOLOGY | 2015年 / 39卷 / 04期

关键词：

Anti-GAD; ARRON; autoimmune optic neuropathy; autoimmune retinopathy; optic nerve autoantibody; retinal autoantibody;

D O I：

10.3109/01658107.2015.1050744

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Autoimmune-related retinopathy and optic neuropathy is characterized by visual loss in the presence of antibodies against retina or optic nerve antigens in the absence of neoplasia. We report a case with progressive central visual loss accompanied by latent autoimmune diabetes in an adult. Visual fields, multimodal imaging and electrophysiological testing showed characteristic changes without evidence of neoplasia on positron emission tomography. Immunologic testing revealed abnormal reactivity against a 20 kDa optic nerve antigen and 40 kDa and 62 kDa retina antigens along with antibodies against anti-glutamic acid decarboxylase, a constellation which we believe to be unique.

引用

页码：195 / 200

页数：6

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