Splice variants of androgen receptor and prostate cancer

被引：5
作者：
Caffo, Orazio [1 ]
Maines, Francesca [1 ]
Veccia, Antonello [1 ]
Kinspergher, Stefania [1 ]
Galligioni, Enzo [1 ]
机构：
[1] Santa Chiara Hosp, Dept Med Oncol, I-38100 Largo Medaglie Doro, Trento, Italy
来源：
ONCOLOGY REVIEWS | 2016年 / 10卷 / 01期
关键词：
Prostate cancer; splice variants; enzalutamide; abiraterone; cabazitaxel;
D O I：
10.4081/oncol.2016.297
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Over the last ten years, two new-generation hormonal drugs and two chemotherapeutic agents have been approved for the treatment of metastatic castration-resistant prostate cancer. Unfortunately, some patients have primary resistance to them and the others eventually develop secondary resistance. It has recently been suggested that the presence of androgen receptor splice variants plays a leading role in the primary and secondary resistance to the new hormonal drugs. whereas their presence seem to have only a partial effect on the activity of the chemotherapeutic agents. The aim of this paper is to review the published data concerning the role of androgen receptor splice variants in prostate cancer biology, and their potential use as biomarkers when making therapeutic decisions.
引用
收藏
页码：14 / 18
页数：5
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