Insulin-induced hypoglycemia stimulates both adrenaline and noradrenaline release from adrenal medulla in 21-day-old rats

被引：9

作者：

Fujino, Y

Fujii, T

机构：

[1] Department of Pharmacology, Teikyo University School of Medicine, Tokyo 173, 2-11-1, Kaga, Itabashi-Ku

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1995年 / 69卷 / 04期

关键词：

adrenal chromaffin cell; hypoglycemia; catecholamine release; exocytosis; infant rat;

D O I：

10.1254/jjp.69.413

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

It has been well-established that insulin-induced hypoglycemia evokes preferential adrenaline release from the adrenal medulla in fasted adult rats. The present study examined the responsiveness to hypoglycemia in fasted 21-day-old and 8-week-old rats. The recovery of adrenaline in the chromaffin granule fraction prepared from the 8-week-old rat adrenal homogenate decreased 30 min after subcutaneous injection of 3 U/kg insulin, whereas the recovery of both adrenaline and noradrenaline was diminished in 21-day-old rats. In electron microscopy, Omega-shaped profiles,indicative of exocytosis, were frequently observed in adrenaline- and noradrenaline-storing cells of 21-day-old rats. These results indicate that the responsiveness of the noradrenaline-storing cells to hypoglycemia in 21-day-old rats is different from that in young adult rats.

引用

页码：413 / 420

页数：8

共 21 条

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