HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ANALYSIS OF BENZODIAZEPINES USING DIODE-ARRAY, ELECTROCHEMICAL AND THERMOSPRAY MASS-SPECTROMETRIC DETECTION

被引：21
作者：
LURIE, IS
COOPER, DA
KLEIN, RFX
机构：
[1] Special Testing and Research Laboratory, Drug Enforcement Administration, McLean, VA 22102-3494
来源：
JOURNAL OF CHROMATOGRAPHY | 1992年 / 598卷 / 01期
关键词：
D O I：
10.1016/0021-9673(92)85114-9
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Twenty benzodiazepines were examined via a combination of high-performance liquid chromatography (HPLC)-diode array-dual electrochemical detection and HPLC-thermospray mass spectrometric detection. Although UV detection at 230 nm resulted in extensive overlap of the benzodiazepines, each compound gave unique UV spectra. Twenty percent of the benzodiazepines tested gave response ratios via oxidation detection, and the values obtained were unique. All compounds except chlorazepate gave MH+ ions as the base peak via thermospray-mass spectrometric detection with filament off; additional ions were detected for many compounds. Using single ion chromatograms all benzodiazepines can be chromatographically resolved.
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页码：59 / 66
页数：8
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  • [11] LIQUID-CHROMATOGRAPHIC SEPARATION OF SOME COMMON BENZODIAZEPINES AND THEIR METABOLITES
    NOGGLE, FT
    CLARK, CR
    DERUITER, J
    [J]. JOURNAL OF LIQUID CHROMATOGRAPHY, 1990, 13 (20): : 4005 - 4021
  • [12] THERMOLYSIS OF 1,4-BENZODIAZEPINES DURING GAS CHROMATOGRAPHY AND MASS SPECTROSCOPY
    SADEE, W
    VANDERKL.E
    [J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1971, 60 (01) : 135 - &
  • [13] ONLINE ELECTROCHEMICAL DETECTION OF OXIDISABLE ORGANIC-MOLECULES OF PHARMACEUTICAL IMPORTANCE
    SMYTH, WF
    BURMICZ, JS
    IVASKA, A
    [J]. ANALYST, 1982, 107 (1278) : 1019 - 1025
  • [14] A STUDY OF THE ELECTROCHEMICAL OXIDATION OF SOME 1,4-BENZODIAZEPINES
    SMYTH, WF
    IVASKA, A
    [J]. ANALYST, 1985, 110 (11) : 1377 - 1379
  • [15] COLLECTION OF ANALYTICAL DATA FOR BENZODIAZEPINES AND BENZOPHENONES - APPENDIX
    WESTON, SI
    JAPP, M
    PARTRIDGE, J
    OSSELTON, MD
    [J]. JOURNAL OF CHROMATOGRAPHY, 1991, 538 (02): : 277 - 284
  • [16] APPLICATION OF HIGH-PRESSURE LIQUID-CHROMATOGRAPHY TO THE FORENSIC ANALYSIS OF SEVERAL BENZODIAZEPINES
    WITTWER, JD
    [J]. JOURNAL OF LIQUID CHROMATOGRAPHY, 1980, 3 (11): : 1713 - 1724
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