HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ANALYSIS OF BENZODIAZEPINES USING DIODE-ARRAY, ELECTROCHEMICAL AND THERMOSPRAY MASS-SPECTROMETRIC DETECTION

被引：21
作者：
LURIE, IS
COOPER, DA
KLEIN, RFX
机构：
[1] Special Testing and Research Laboratory, Drug Enforcement Administration, McLean, VA 22102-3494
来源：
JOURNAL OF CHROMATOGRAPHY | 1992年 / 598卷 / 01期
关键词：
D O I：
10.1016/0021-9673(92)85114-9
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Twenty benzodiazepines were examined via a combination of high-performance liquid chromatography (HPLC)-diode array-dual electrochemical detection and HPLC-thermospray mass spectrometric detection. Although UV detection at 230 nm resulted in extensive overlap of the benzodiazepines, each compound gave unique UV spectra. Twenty percent of the benzodiazepines tested gave response ratios via oxidation detection, and the values obtained were unique. All compounds except chlorazepate gave MH+ ions as the base peak via thermospray-mass spectrometric detection with filament off; additional ions were detected for many compounds. Using single ion chromatograms all benzodiazepines can be chromatographically resolved.
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页码：59 / 66
页数：8
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