THE CRITICAL ROLE OF INTERLEUKIN-6, INTERLEUKIN-1B AND MACROPHAGE COLONY-STIMULATING FACTOR IN THE PATHOGENESIS OF BONE-LESIONS IN MULTIPLE-MYELOMA

被引：49

作者：

BATAILLE, R ^{[1
]}

CHAPPARD, D ^{[1
]}

KLEIN, B ^{[1
]}

机构：

[1] FAC MED ST ETIENNE, LBTO, F-42023 PARIS 2, FRANCE

来源：

INTERNATIONAL JOURNAL OF CLINICAL & LABORATORY RESEARCH | 1992年 / 21卷 / 04期

关键词：

MULTIPLE MYELOMA; BONE RESORPTION; OSTEOCLAST-ACTIVATING FACTORS; INTERLEUKIN-6;

D O I：

10.1007/BF02591662

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Lytic bone lesions and hypercalcemia are common features of multiple myeloma. In contrast, they are exceptional in other B-cell malignancies. Myeloma bone involvement is related to an uncoupling process associating increased osteoclastic resorption with decreased bone formation. Several osteoclast-activating factors, such as interleukin-1, macrophage colony-stimulating factor, and interleukin-6, are involved in this process. However, interleukin-6, the major myeloma cell growth factor, plays a critical role in myeloma-induced bone resorption.

引用

页码：283 / 287

页数：5

共 59 条

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