THE CRITICAL ROLE OF INTERLEUKIN-6, INTERLEUKIN-1B AND MACROPHAGE COLONY-STIMULATING FACTOR IN THE PATHOGENESIS OF BONE-LESIONS IN MULTIPLE-MYELOMA

被引：49
作者：
BATAILLE, R [1 ]
CHAPPARD, D [1 ]
KLEIN, B [1 ]
机构：
[1] FAC MED ST ETIENNE, LBTO, F-42023 PARIS 2, FRANCE
来源：
INTERNATIONAL JOURNAL OF CLINICAL & LABORATORY RESEARCH | 1992年 / 21卷 / 04期
关键词：
MULTIPLE MYELOMA; BONE RESORPTION; OSTEOCLAST-ACTIVATING FACTORS; INTERLEUKIN-6;
D O I：
10.1007/BF02591662
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Lytic bone lesions and hypercalcemia are common features of multiple myeloma. In contrast, they are exceptional in other B-cell malignancies. Myeloma bone involvement is related to an uncoupling process associating increased osteoclastic resorption with decreased bone formation. Several osteoclast-activating factors, such as interleukin-1, macrophage colony-stimulating factor, and interleukin-6, are involved in this process. However, interleukin-6, the major myeloma cell growth factor, plays a critical role in myeloma-induced bone resorption.
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收藏
页码：283 / 287
页数：5
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