EFFECTS OF ADENOSINE ON CANINE PENILE ERECTION

被引：44

作者：

TAKAHASHI, Y ^{[1
]}

ISHII, N ^{[1
]}

LUE, TF ^{[1
]}

TANAGHO, EA ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO,SCH MED,DEPT UROL,SAN FRANCISCO,CA 94143

来源：

JOURNAL OF UROLOGY | 1992年 / 148卷 / 04期

关键词：

ADENOSINE; PENILE ERECTION; DOGS;

D O I：

10.1016/S0022-5347(17)36901-X

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

We investigated the hemodynamic effects of intracavernous injection of adenosine on canine penile erection. In all ten dogs studied, adenosine induced a dose-dependent increase of intracavernous pressure (ICP). Adenosine (0.67 to 15 mug./kg.,B.W.) increased arterial blood flow by 83 to 325 percent above baseline levels and also increased venous resistance, which resulted in a full erection (ICP = 80 to 140 cm. H2O) for one to 7 minutes. The repeatability of the adenosine effect was confirmed in eight dogs. We found that adenosine, by virtue of its smooth muscle relaxation properties, can induce a dose-dependent increase of ICP and cause a full erection in dogs.

引用

页码：1323 / 1325

页数：3

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