Therapeutic potential of mesenchymal stem cell based therapy for osteoarthritis

被引：53
作者：
Burke, John [1 ]
Hunter, Monte [1 ]
Kolhe, Ravindra [2 ]
Isales, Carlos [1 ,4 ]
Hamrick, Mark [3 ,4 ]
Fulzele, Sadanand [1 ,4 ,5 ]
机构：
[1] Georgia Regents Univ, Dept Orthoped, Augusta, GA USA
[2] Georgia Regents Univ, Dept Pathol, Augusta, GA USA
[3] Georgia Regents Univ, Dept Cell Biol & Anat, Augusta, GA USA
[4] Georgia Regents Univ, Inst Regenerat & Reparat Med, Augusta, GA USA
[5] Augusta Univ, Dept Orthoped Surg, Augusta, GA 30904 USA
来源：
CLINICAL AND TRANSLATIONAL MEDICINE | 2016年 / 5卷
关键词：
Osteoarthritis; Stem cell; ADSC; Cell therapy;
D O I：
10.1186/s40169-016-0112-7
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Osteoarthritis (OA) is a chronic degenerative disease affecting articular cartilage in joints, and it is a leading cause of disability in the United States. Current pharmacological treatment strategies are ineffective to prevent the OA progression; however, cellular therapies have the potential to regenerate the lost cartilage, combat cartilage degeneration, provide pain relief, and improve patient mobility. One of the most promising sources of cellular regenerative medicine is from mesenchymal stem cells (MSCs). MSCs can be isolated from adipose tissue, bone marrow, synovial tissue, and other sources. The aim of this review is to compile recent advancement in cellular based therapy more specifically in relation to MSCs in the treatment of osteoarthritis.
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页数：8
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