ANTIESTROGEN INDUCED SYNTHESIS OF TRANSFORMING GROWTH-FACTOR-BETA IN BREAST-CANCER PATIENTS

被引：4
作者：
MIRZA, MR
机构：
[1] Department of Medicine, The Aga Khan University Hospital, Karachi74800, Stadium Road
来源：
CANCER TREATMENT REVIEWS | 1991年 / 18卷 / 02期
关键词：
D O I：
10.1016/0305-7372(91)90011-N
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Estrogen receptor-negative human breast cancer is usually an aggressive, hormone independent tumour. Recent studies show that growth of these tumours could be influenced by anti-estrogens. Anti-estrogens appear to stimulate the production of Transforming Growth Factor-beta (TGF-β) in hormone dependent as well as independent cell lines suggesting as a result inhibition of cellular proliferation of these cell lines by TGF-β through an autocrine/paracrine mechanism. © 1991.
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页码：145 / 148
页数：4
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