PENICILLIN PRODUCTION BY MUTANTS OF PENICILLIUM-CHRYSOGENUM RESISTANT TO POLYENE MACROLIDE ANTIBIOTICS

被引：3

作者：

LUENGO, JM ^{[1
]}

REVILLA, G ^{[1
]}

LOPEZ, MJ ^{[1
]}

VILLANUEVA, JR ^{[1
]}

MARTIN, JF ^{[1
]}

机构：

[1] UNIV SALAMANCA,FAC CIENCIAS & FARM,DEPT MICROBIOL,SALAMANCA,SPAIN

来源：

BIOTECHNOLOGY LETTERS | 1979年 / 1卷 / 06期

关键词：

D O I：

10.1007/BF01386994

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Polyene-resistant mutants of Penicillium chrysogenum Wis. 54-1255 have been obtained by stepwise selection in increasing concentrations of polyene antibiotics. From the parent strain, sensitive to 10 μg/ml of polyene antibiotics, mutants resistant to fungimycin (1.3 mg/ml), amphotericin B (0. 5 mg/ml), or nystatin (167 μg//ml) were obtained. Their penicillin production is different from that of the parent strain and in particular some of the fungimycin-resistant mutants produce higher levels of penicillin. © 1979 Kluwer Academic Publishers.

引用

页码：233 / 238

页数：6

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