RETINOIDS ENHANCE MITOGENESIS BY TUMOR PROMOTOR AND POLYPEPTIDE GROWTH-FACTORS

被引：53
作者：
DICKER, P
ROZENGURT, E
机构：
[1] Imperial Cancer Research Fund Lincoln's Inn Fields, London
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 91卷 / 04期
关键词：
D O I：
10.1016/0006-291X(79)91195-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Retinoids at low concentrations strikingly enhance the growth-promoting activity of polypeptides like epidermal growth factor, insulin, vasopressin and fibroblast-derived growth factor and of 12-0-tetradecanoyl-phorbol-13-acetate, a potent tumour-promoting agent. Retinoids enhance both DNA synthesis and cell proliferation in quiescent cultures of mouse 3T3 cells and of hamster Nil-8 cells. These findings contrast with previous reports showing growth inhibitory properties of retinoids. © 1979.
引用
收藏
页码：1203 / 1210
页数：8
相关论文
共 21 条
[1]   18,000 MOLECULAR-WEIGHT POLYPEPTIDE INDUCES EARLY EVENTS AND STIMULATES DNA-SYNTHESIS IN CULTURED-CELLS [J].
BOURNE, HR ;
ROZENGURT, E .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (12) :4555-4559
[2]   INHIBITION OF EPIDERMAL GROWTH-FACTOR BINDING TO SURFACE RECEPTORS BY TUMOR PROMOTORS [J].
BROWN, KD ;
DICKER, P ;
ROZENGURT, E .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1979, 86 (04) :1037-1043
[3]   STIMULATION OF DNA-SYNTHESIS BY TUMOR PROMOTER AND PURE MITOGENIC FACTORS [J].
DICKER, P ;
ROZENGURT, E .
NATURE, 1978, 276 (5689) :723-726
[4]   VITAMIN-A-INDUCED DENSITY-DEPENDENT INHIBITION OF L-CELL PROLIFERATION [J].
DION, LD ;
BLALOCK, JE ;
GIFFORD, GE .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1977, 58 (03) :795-801
[5]  
GLOVER J, 1947, BIOCHEM J, V41, P95
[6]  
HEILMAN C, 1975, FED PROC, V34, P822
[7]   CHARACTERIZATION OF THE ACTION OF RETINOIDS ON MOUSE FIBROBLAST CELL-LINES [J].
JETTEN, AM ;
JETTEN, MER ;
SHAPIRO, SS ;
POON, JP .
EXPERIMENTAL CELL RESEARCH, 1979, 119 (02) :289-299
[8]  
KENSLER TW, 1978, CANCER RES, V38, P771
[9]   INHIBITORY EFFECTS OF RETINOIC ACID OR RETINYL ACETATE ON GROWTH OF UNTRANSFORMED, TRANSFORMED, AND TUMOR-CELLS INVITRO [J].
LOTAN, R ;
NICOLSON, GL .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1977, 59 (06) :1717-1722
[10]   RETINOIDS, A NEW CLASS OF COMPOUNDS WITH PROPHYLACTIC AND THERAPEUTIC ACTIVITIES IN ONCOLOGY AND DERMATOLOGY [J].
MAYER, H ;
BOLLAG, W ;
HANNI, R ;
RUEGG, R .
EXPERIENTIA, 1978, 34 (09) :1105-1119
123