PLASMINOGEN-ACTIVATOR INHIBITOR-1 RESPONSE TO A CARBOHYDRATE MEAL IN OBESE SUBJECTS

被引：13
|
作者：
MEDVESCEK, M [1 ]
KEBER, D [1 ]
STEGNAR, M [1 ]
BOROVNICAR, A [1 ]
机构：
[1] EDVARD KARDELJ UNIV, MED CTR, TRNOVO HOSP INTERNAL MED, YU-61000 LJUBLJANA, YUGOSLAVIA
来源：
FIBRINOLYSIS | 1990年 / 4卷
关键词：
Carbohydrate meal; Obesity; Plasminogen activator inhibitor;
D O I：
10.1016/0268-9499(90)90371-P
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The response of PAI-1 to a high-caloric carbohydrate meal was studied in two groups of healthy volunteers: 10 younger, lean and 11 middle-aged obese individuals. Both groups underwent a 4 hr morning observation period under two different conditions - with a carbohydrate load and fast. In both groups a significant meal-related peak in PAI activity occurred between 60 and 120 min, being of approximately the same magnitude in both groups. PAI antigen showed a plateau after the meal instead of a fall during fast. The obese group displayed much higher basal levels of PAI activity and also antigen, insulin and triglycerides, as well as insulin and glucose levels after the meal. © 1990.
引用
收藏
页码：89 / 90
页数：2
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