Clinico-Functional Features of Concomitant Chronic Bronchitis and Chronic Obstructive Pulmonary Disease and Metabolic Syndrome in the Yakut Ethnic Group

Objective. Studing of clinical and functional characteristics of the combined course of chronic bronchitis (CB) and chronic obstructive pulmonary disease (COPD) and metabolic syndrome (MS) in Yakut ethnic group. Materials and methods. We have examined 88 patients Yakut with chronic bronchitis and COPD in combination with MS. The median age was 50,9 +/- 0,91 years. The comparison group consisted of 60 patients Yakut with chronic bronchitis and COPD without metabolic syndrome, where the average age was equal to 48.9 +/- 1.35 years. Peculiarities of clinical manifestations and indicators of bronchial patency were also studied. Results. In the combined course of CB/COPD and MS in Yakut ethnic group, we found more severe clinical manifestations in comparison with the group without metabolic syndrome, in the form of a more severe cough syndrome, more severe dyspnea, sputum gain and changes its character, increasing the frequency of exacerbations. In the combined course of chronic bronchitis and chronic obstructive pulmonary disease and metabolic syndrome in Yakut ethnic group, we found that lung function compared with isolated over these diseases were not significantly different. However, in the combined courses more pronounced disorders of respiratory function in the form of reduced forced vital capacity (FVC), decline in forced expiratory volume in one second FEV1, FEV1/FVC ratio increase > 70% were observed in our research. Conclusion. Combined course of CB/COPD and MS is characterized by more severe changes in the clinical manifestations. Our findings indicate the presence of more pronounced changes in respiratory function in patients with associated course of CB/COPD and MS.