CONTROL OF ACETYLOCHOLINE SYNTHESIS - INHIBITION OF CHOLINE ACETYLTRANSFERASE BY ACETYLCHOLINE

被引：84

作者：

KAITA, AA

GOLDBERG, AM

机构：

[1] Department of Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana

来源：

JOURNAL OF NEUROCHEMISTRY | 1969年 / 16卷 / 07期

关键词：

D O I：

10.1111/j.1471-4159.1969.tb05964.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abstract— The inhibition of choline acetyltransferase by acetylcholine in vitro occurs at a concentration of 10 mm and increases progressively to 45 per cent at a concentration of 100 mm. The inhibition is competitive for choline and noncompetitive for acetyl‐CoA. It is suggested that the synthesis of acetylcholine may be controlled by its accumulation in synaptic vesicles. Copyright © 1969, Wiley Blackwell. All rights reserved

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页码：1185 / &

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