METHOD DEVELOPMENT AND VALIDATION OF CAPECITABINE IN TABLETS BY RP-HPLC METHOD

被引：0

作者：

Rao, M. Prasada ^{[1
]}

Leelavathi, K. ^{[1
]}

Chandreshta, N. ^{[1
]}

Sowjanya, V. ^{[1
]}

Sireesha, I. ^{[1
]}

Rajani, I. ^{[1
]}

Premi, V. V. Naga ^{[1
]}

机构：

[1] MAM Coll Pharm, Dept Pharmaceut Anal, Narasaraopet 522091, Guntur, India

来源：

INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2016年 / 3卷 / 05期

关键词：

Capecitabine; RP-HPLC; Develosil ODS-MG-5;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An isocratic reverse phase liquid chromatography (RP-HPLC) method has been developed and subsequently validated for the determination of Capecitabine in Bulk and its pharmaceutical formulation. Separation was achieved with a Develosil (ODS-MG-5; 100 x 4.6mm I. D; particle size 5 mu m) Column and buffer Methanol (450: 550) v/v as eluent and purified water, methanol and acetonitrile(600: 350: 50) v/v as diluent at flow rate 1.0 mL/min and the Column temperature was 40 degrees C. The described method of Capecitabine is linear over a range of 6 mu g/mL to 30 mu g/mL. The method precision for the determination of assay was below 2.0% RSD.

引用

页码：492 / 507

页数：16