Toll-like receptors in the pathogenesis of autoimmune diseases: recent and emerging translational developments

被引：76

作者：

Duffy, Laura ^{[1
]}

O'Reilly, Steven C. ^{[1
]}

机构：

[1] Northumbria Univ, Immunol & Cell Biol Grp, Fac Hlth & Life Sci, Ellison Bldg, Newcastle Upon Tyne NE2 8ST, Tyne & Wear, England

来源：

IMMUNOTARGETS AND THERAPY | 2016年 / 5卷

关键词：

autoimmunity; toll-like receptors; danger signals; arthritis;

D O I：

10.2147/ITT.S89795

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autoinflammatory diseases are defined as the loss of self-tolerance in which an inflammatory response to self-antigens occurs, which are a significant global burden. Toll-like receptors are key pattern recognition receptors, which integrate signals leading to the activation of transcription factors and ultimately proinflammatory cytokines. Recently, it has become apparent that these are at the nexus of autoinflammatory diseases making them viable and attractive drug targets. The aim of this review was to evaluate the role of innate immunity in autoinflammatory conditions alongside the role of negative regulation while suggesting possible therapeutic targets.

引用

页码：69 / 80

页数：12

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