Role of the fibrinolytic system in preventing myocardial infarction

被引：29
作者：
Vaughan, DE
Rouleau, JL
Pfeffer, MA
机构：
[1] VET AFFAIRS MED CTR, NASHVILLE, TN 37212 USA
[2] MONTREAL HEART INST, MONTREAL, PQ H1T 1C8, CANADA
[3] HARVARD UNIV, BRIGHAM & WOMENS HOSP, SCH MED, DIV CARDIOVASC, BOSTON, MA 02115 USA
来源：
EUROPEAN HEART JOURNAL | 1995年 / 16卷
关键词：
fibrinolysis; renin-angiotensin system; plasminogen activator inhibitor-1; tissue-type plasminogen activator; angiotensin converting enzyme;
D O I：
10.1093/eurheartj/16.suppl_K.31
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Activation of the renin-angiotensin system (RAS) has been implicated in the pathogenesis of acute myocardial infarction (AMI). Similarly, reduced fibrinolytic activity has been associated with an increased risk of AMI. Evidence is now accumulating that the RAS plays an important role in the regulation of fibrinolysis and that pharmacological interruption of the RAS exerts a positive effect on endogenous fibrinolytic balance. This relationship appears to provide a partial explanation for the newly recognized effect of angiotensin converting enzyme inhibitors in preventing AMI.
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收藏
页码：31 / 36
页数：6
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