REGION-SPECIFIC EFFECTS OF CHRONIC LITHIUM ADMINISTRATION ON NEUROPEPTIDE-Y AND SOMATOSTATIN MESSENGER-RNA EXPRESSION IN THE RAT-BRAIN

被引：43
作者：
ZACHRISSON, O
MATHE, AA
STENFORS, C
LINDEFORS, N
机构：
[1] KAROLINSKA HOSP,KAROLINSKA INST,DEPT CLIN NEUROSCI,S-17176 STOCKHOLM,SWEDEN
[2] KAROLINSKA INST,ST GORANS HOSP,DEPT CLIN NEUROSCI,PSYCHIAT SECT,S-11281 STOCKHOLM,SWEDEN
[3] KAROLINSKA HOSP,KAROLINSKA INST,DEPT CLIN CHEM,S-17176 STOCKHOLM,SWEDEN
来源：
NEUROSCIENCE LETTERS | 1995年 / 194卷 / 1-2期
关键词：
LITHIUM; MANIC-DEPRESSIVE ILLNESS; NEUROPEPTIDE Y; SOMATOSTATIN; MESSENGER-RNA EXPRESSION; IN SITU HYBRIDIZATION; RAT BRAIN;
D O I：
10.1016/0304-3940(95)11735-F
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The aim of this study was to examine the effects of 4-week lithium (Li+) food supplementation on neuropeptide mRNA expression in the rat brain. In situ hybridisation was used to determine the effects on the expression of neuropeptide Y (NPY) and somatostatin (SS) mRNA. Increases in NPY mRNA levels were seen in the hippocampus, layers II-III of the entorhinal cortex, nucleus accumbens shell and in the medial caudate-putamen. Increases in SS mRNB expression were seen in the layers IV-VI of the entorhinal cortex and in the lateral caudate putamen. Thus, Li+ appears to affect discrete populations of NPY and SS mRNA expressing neurons, with possible relevance to beneficial effects of Li+ in affective disorders.
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页码：89 / 92
页数：4
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