TRANSFERRIN RECEPTORS ASSOCIATE WITH DRUG-RESISTANCE IN CANCER-CELLS

被引：27

作者：

BARABAS, K ^{[1
]}

FAULK, WP ^{[1
]}

机构：

[1] HUNGARIAN ACAD SCI, CTR BIOL RES, INST BIOPHYS, H-6701 SZEGED, HUNGARY

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 197卷 / 02期

关键词：

D O I：

10.1006/bbrc.1993.2536

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transferrin mediates its growth promoting properties through transferrin receptors, which are increased on cancer cells. We have studied drug- sensitive and drug-resistant cancer cells by using quantitative flow cytometry with fluorochrome labelled transferrin and antibody to transferrin receptor, and we have found that drug-resistant cells have more transferrin receptors than drug-sensitive cells. This finding was confirmed and extended by using isotopically labelled ligand and by correcting for differences in cell surface areas. We also found that the number of transferrin receptors could be down-regulated by calcium channel blockers, and that such downregulation diminished drug resistance, suggesting a hitherto unrecognised role for transferrin receptors in drug resistance. © 1993 Academic Press, Inc.

引用

页码：702 / 708

页数：7

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