REACTIVATION OF CHRONIC HEPATITIS-C AFTER WITHDRAWAL OF IMMUNOSUPPRESSIVE THERAPY

被引：40
作者：
GRUBER, A
LUNDBERG, LG
BJORKHOLM, M
机构：
[1] Department of Internal Medicine, Section of Haematology and Immunology, Karolisnka Hospital, Stockholm
来源：
JOURNAL OF INTERNAL MEDICINE | 1993年 / 234卷 / 02期
关键词：
CHRONIC; HEPATITIS-C; IMMUNOSUPPRESSION;
D O I：
10.1111/j.1365-2796.1993.tb00734.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A patient with immune-mediated thrombocytopenia (ITP) and chronic hepatitis C virus (HCV) infection for 11 years was given immunosuppressive treatment because of an activation of his ITP. After 6 weeks of treatment with cyclophosphamide, cyclosporin A and cortisone the patient decided not to continue taking his medication. One month later he was readmitted to hospital due to fever, cough and jaundice. Clinical investigation revealed his condition to be caused by an activation of his HCV infection. It is concluded that, in parallel to the situation in hepatitis B, immunosuppressive treatment of patients with HCV infection may lead to increased viral replication, resulting in severe liver damage when immunocompetence is regained.
引用
收藏
页码：223 / 225
页数：3
相关论文
共 14 条
  • [1] DIENSTAG JL, 1986, CLIN APPROACH INFECT, P325
  • [2] FAN FS, 1991, BONE MARROW TRANSPL, V8, P417
  • [3] DEMONSTRATION OF VIREMIA PATTERNS IN HEMOPHILIACS TREATED WITH HEPATITIS-C-VIRUS-CONTAMINATED FACTOR-VIII CONCENTRATES
    GARSON, JA
    TUKE, PW
    MAKRIS, M
    BRIGGS, M
    MACHIN, SJ
    PRESTON, FE
    TEDDER, RS
    [J]. LANCET, 1990, 336 (8722) : 1022 - 1025
  • [4] LATE SEROCONVERSION AND HIGH CHRONICITY RATE OF HEPATITIS-C VIRUS-INFECTION IN PATIENTS WITH HEMATOLOGIC DISORDERS
    GRUBER, A
    NORDER, H
    MAGNIUS, L
    ROTZEN, M
    RUBIO, C
    GRILLNER, L
    BJORKHOLM, M
    [J]. ANNALS OF ONCOLOGY, 1993, 4 (03) : 229 - 234
  • [5] REACTIVATION OF CHRONIC HEPATITIS B-VIRUS INFECTION BY CANCER-CHEMOTHERAPY
    HOOFNAGLE, JH
    DUSHEIKO, GM
    SCHAFER, DF
    JONES, EA
    MICETICH, KC
    YOUNG, RC
    COSTA, J
    [J]. ANNALS OF INTERNAL MEDICINE, 1982, 96 (04) : 447 - 449
  • [6] FULMINANT HEPATITIS-C VIRAL-INFECTION AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION
    KANAMORI, H
    FUKAWA, H
    MARUTA, A
    HARANO, H
    KODAMA, F
    MATSUZAKI, M
    MIYASHITA, H
    MOTOMURA, S
    OKUBO, T
    YOSHIBA, M
    SEKIYAMA, K
    [J]. AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 1992, 303 (02) : 109 - 111
  • [7] HEPATITIS-C VIRUS-INFECTION IN PATIENTS UNDERGOING ALLOGENEIC BONE-MARROW TRANSPLANTATION
    LOCASCIULLI, A
    BACIGALUPO, A
    VANLINT, MT
    TAGGER, A
    UDERZO, C
    PORTMANN, B
    SHULMAN, HM
    ALBERTI, A
    [J]. TRANSPLANTATION, 1991, 52 (02) : 315 - 318
  • [8] FULMINANT-HEPATITIS DUE TO REACTIVATION OF CHRONIC HEPATITIS-B VIRUS-INFECTION AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION
    PARIENTE, EA
    GOUDEAU, A
    DUBOIS, F
    DEGOTT, C
    GLUCKMAN, E
    DEVERGIE, A
    BRECHOT, C
    SCHENMETZLER, C
    BERNUAU, J
    [J]. DIGESTIVE DISEASES AND SCIENCES, 1988, 33 (09) : 1185 - 1191
  • [9] PINTO PC, 1990, CANCER-AM CANCER SOC, V65, P878, DOI 10.1002/1097-0142(19900215)65:4<878::AID-CNCR2820650409>3.0.CO
  • [10] 2-K
12