OBSESSIVE-COMPULSIVE DISORDER IN HUNTINGTONS-DISEASE

被引：128
作者：
CUMMINGS, JL
CUNNINGHAM, K
机构：
[1] VET ADM MED CTR BRENTWOOD,PSYCHIAT SERV,BEHAV NEUROSCI SECT,LOS ANGELES,CA 90073
[2] UNIV CALIF LOS ANGELES,SCH MED,DEPT NEUROL,LOS ANGELES,CA 90024
[3] UNIV CALIF LOS ANGELES,SCH MED,DEPT PSYCHIAT,LOS ANGELES,CA 90024
[4] UNIV CALIF LOS ANGELES,SCH MED,DEPT BIOBEHAV SCI,LOS ANGELES,CA 90024
来源：
BIOLOGICAL PSYCHIATRY | 1992年 / 31卷 / 03期
关键词：
D O I：
10.1016/0006-3223(92)90049-6
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Two patients with Huntington's disease (HD) and obsessive-compulsive disorder (OCD) are reported. The OCD was manifested by repetitive, stereotyped, complex, egodystonic behaviors that were disabling. These cases and other neurological syndromes with OCD (Gilles de la Tourette syndrome, neuroacanthocytosis, postencephalitic parkinsonism, caudate infarction, carbon monoxide poisoning, manganese intoxication, anoxia, progressive supranuclear palsy, Sydenham's chorea, and frontal lobe lesions) indicate that the frontal lobe, caudate nucleus, and globus pallidus are members of a complex circuit that plays a key role in mediating the symptoms of OCD. Evidence of excitatory subcortical output to cortex is shared by many neurological disorders manifesting OCD.
引用
收藏
页码：263 / 270
页数：8
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