FACILE ENZYMATIC PREPARATION OF ENANTIOMERIC BETA-LACTAMS

被引：0

作者：

NAGAI, H

SHIOZAWA, T

ACHIWA, K

TERAO, Y

机构：

[1] UNIV SHIZUOKA, GRAD SCH NUTR & ENVIRONM SCI, DIV ENVIRONM HLTH SCI, 51-2 YADA, OYA, SHIZUOKA 422, JAPAN

[2] UNIV SHIZUOKA, SCH PHARMACEUT SCI, OYA, SHIZUOKA 422, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1992年 / 40卷 / 08期

关键词：

BETA-LACTAM; LIPASE; RESOLUTION; HYDROLYSIS; ESTERIFICATION;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Optically active beta-lactams were obtained conveniently by lipase-catalyzed enantioselective hydrolysis of 1-acyloxymethyl-2-azetidinones and esterification of 1-hydroxymethyl-3,3-dimethyl-2-azetidinone with vinyl acetate in organic solvent.

引用

页码：2227 / 2229

页数：3

共 11 条

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