SYNTHESIS AND ANTIFUNGAL ACTIVITY OF SOME NEW BENZIMIDAZOLE DERIVATIVES

被引：11

作者：

GOKER, H

ERTAN, R

AKGUN, H

YULUG, N

机构：

[1] MIDDLE E TECH UNIV,DEPT CHEM,ANKARA,TURKEY

[2] HACETTEPE UNIV,FAC MED,DEPT MICROBIOL,ANKARA,TURKEY

来源：

ARCHIV DER PHARMAZIE | 1991年 / 324卷 / 05期

关键词：

D O I：

10.1002/ardp.19913240505

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Synthesis and antifungal evaluation of 5-ethoxycarbonyl-2-(substituted-benzyl or phenoxymethyl)benzimidazoles are reported. Structures of the compounds were elucidated with IR-, H-1-NMR-, C-13-NMR-, mass-spectra and elemental analysis. Preliminary results show that none of the synthesized benzimidazole derivatives has antifungal activity at the concentration of 100-mu-g/ml against Candida parapsilosis, Candida stellatoidea, and Candida pseudotropicalis.

引用

页码：283 / 286

页数：4