INSULIN-STIMULATED GLUCOSE-TRANSPORT REGULATED BY ADENYLATE-CYCLASE SYSTEM IN RAT ADIPOCYTES

被引：6
|
作者：
SHIRAKURA, S [1 ]
TOKUMITSU, Y [1 ]
机构：
[1] HOKKAIDO UNIV,FAC PHARMACEUT SCI,DEPT PHYSIOL CHEM,SAPPORO,HOKKAIDO 060,JAPAN
来源：
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-PHYSIOLOGY | 1990年 / 96卷 / 04期
关键词：
D O I：
10.1016/0300-9629(90)90670-N
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
1. 1. In rat adipocytes, there was an inverse correlation between insulin-stimulated 2-deoxyglucose (2-DG) uptake and cAMP levels, indicating that cAMP suppressed the 2-DG uptake stimulated by insulin. 2. 2. This inhibitory effect of cAMP was due to suppression of translocation of glucose transporters rather than that of insulin-binding to its receptors. 3. 3. Phosphodiesterase inhibitors (IBMX, Ro 20-1724, and cilostamide) inhibited the 2-DG uptake, which was brought about by direct interaction with glucose transporters in the plasma membranes. © 1990.
引用
收藏
页码：503 / 509
页数：7
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