STRUCTURE AND FUNCTION OF G-PROTEIN COUPLED RECEPTORS

被引：31
|
作者：
LAMEH, J
CONE, RI
MAEDA, S
PHILIP, M
CORBANI, M
NADASDI, L
RAMACHANDRAN, J
SMITH, GM
SADEE, W
机构：
[1] UNIV CALIF SAN FRANCISCO,SCH PHARM,SAN FRANCISCO,CA 94143
[2] NEUREX CORP,MENLO PK,CA 94025
[3] OSAKA UNIV,FAC DENT,DEPT PHARMACOL,SUITA,OSAKA 565,JAPAN
[4] MERCK SHARP & DOHME LTD,W POINT,PA 19486
来源：
PHARMACEUTICAL RESEARCH | 1990年 / 7卷 / 12期
关键词：
adrenergic receptors; G protein coupled receptors; hormone receptors; muscarinic cholinergic receptors; neurotransmitter receptors; second messengers;
D O I：
10.1023/A:1015969301407
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The G protein coupled receptors (GPC-Rs) comprise a large superfamily of genes encoding numerous receptors which all show common structural features, e.g., seven putative membrane spanning domains. Their biological functions are extremely diverse, ranging from vision and olfaction to neuronal and endocrine signaling. The GPC-Rs couple via multiple G proteins to a growing number of recognized second messenger pathway, e.g., cAMP and phosphatidyl inositol turnover. This review summarizes our current knowledge of the molecular mechanisms by which the GPC-Rs activate second messenger systems, and it addresses their regulation and structure. © 1990, Plenum Publishing Corporation. All rights reserved.
引用
收藏
页码：1213 / 1221
页数：9
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