ANTIGONADOTROPIC AND ANTISTEROIDOGENIC ACTIONS OF PEROXIDE IN RAT GRANULOSA-CELLS

被引：67
作者：
MARGOLIN, Y
ATEN, RF
BEHRMAN, HR
机构：
[1] YALE UNIV, SCH MED, DEPT OBSTET GYNECOL, REPROD BIOL SECT, NEW HAVEN, CT 06510 USA
[2] YALE UNIV, SCH MED, DEPT PHARMACOL, NEW HAVEN, CT 06510 USA
来源：
ENDOCRINOLOGY | 1990年 / 127卷 / 01期
关键词：
D O I：
10.1210/endo-127-1-245
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Reactive oxygen species are produced in the ovary. In luteal cells, peroxide abruptly inhibits LH-sensitive cAMP and progesterone production, and may serve a role as a mediator of luteolysis by such mechanisms. The objective of the present studies was to evaluate the acute actions of peroxide in rat granulosa cells. Peroxide at concentrations in the low micromolar range produced a marked and dose-dependent inhibition of FSH-sensitive cAMP accumulation and progesterone production, and depleted cell levels of ATP within 1 min. Longer treatment with peroxide. © 1990 by The Endocrine Society.
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页码：245 / 250
页数：6
相关论文
共 39 条
[1]   INDUCTION OF PEROXIDASE IN CORPORA-LUTEA OF RAT OVARY BY LUTROPIN [J].
AGRAWAL, P ;
LALORAYA, MM .
BIOCHEMICAL JOURNAL, 1977, 166 (02) :205-208
[2]  
BABIOR BM, 1987, OXYGEN RADICALS TISS, P43
[3]   TUMOR NECROSIS FACTOR-A (TNF-A) PRODUCTION AND LOCALIZATION OF MACROPHAGES AND LYMPHOCYTES-T IN THE RABBIT CORPUS-LUTEUM [J].
BAGAVANDOSS, P ;
KUNKEL, SL ;
WIGGINS, RC ;
KEYES, PL .
ENDOCRINOLOGY, 1988, 122 (03) :1185-1187
[4]   LUTEOLYTIC ACTIONS OF PEROXIDE IN RAT OVARIAN-CELLS [J].
BEHRMAN, HR ;
PRESTON, SL .
ENDOCRINOLOGY, 1989, 124 (06) :2895-2900
[5]   ADENINE-DERIVED PURINES INCREASE ADENOSINE-TRIPHOSPHATE (ATP) LEVELS IN THE LUTEAL CELL - EVIDENCE THAT CELL LEVELS OF ATP MAY LIMIT THE STIMULATION OF ADENOSINE-3',5'-MONOPHOSPHATE ACCUMULATION BY LUTEINIZING-HORMONE [J].
BRENNAN, TJ ;
OHKAWA, R ;
GORE, SD ;
BEHRMAN, HR .
ENDOCRINOLOGY, 1983, 112 (02) :499-508
[6]  
BULMER D, 1964, J ANAT, V98, P313
[7]   MORPHOLOGICAL-STUDIES OF THE MICROCIRCULATORY SYSTEM OF PERIOVULATORY OVINE FOLLICLES [J].
CAVENDER, JL ;
MURDOCH, WJ .
BIOLOGY OF REPRODUCTION, 1988, 39 (04) :989-997
[8]   HYDROPEROXIDE METABOLISM IN MAMMALIAN ORGANS [J].
CHANCE, B ;
SIES, H ;
BOVERIS, A .
PHYSIOLOGICAL REVIEWS, 1979, 59 (03) :527-605
[9]   A STUDY ON THE ROLE OF PROTEIN KINASE-C AND INTRACELLULAR CALCIUM IN THE ACTIVATION OF SUPEROXIDE GENERATION [J].
CHRISTIANSEN, NO ;
LARSEN, CS ;
ESMANN, V .
BIOCHIMICA ET BIOPHYSICA ACTA, 1988, 971 (03) :317-324
[10]  
CLARK IA, 1987, OXYGEN RADICALS TISS, P122
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