Effect of inhaled corticosteroids on blood eosinophil count in steroid-naive patients with COPD

被引：41

作者：

Kreindler, James L. ^{[1
]}

Watkins, Michael L. ^{[2
]}

Lettis, Sally ^{[3
]}

Tal-Singer, Ruth ^{[1
]}

Locantore, Nicholas ^{[1
]}

机构：

[1] GlaxoSmithKline Res & Dev Ltd, King Of Prussia, PA USA

[2] GlaxoSmithKline Res & Dev Ltd, Res Triangle Pk, NC USA

[3] GlaxoSmithKline Res & Dev Ltd, Uxbridge, Middx, England

来源：

BMJ OPEN RESPIRATORY RESEARCH | 2016年 / 3卷 / 01期

关键词：

D O I：

10.1136/bmjresp-2016-000151

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Introduction: Sputum and blood eosinophil counts have attracted attention as potential biomarkers in chronic obstructive pulmonary disease (COPD). One question regarding the use of blood eosinophils as a biomarker in COPD is whether their levels are affected by the use of inhaled corticosteroids (ICS), which are commonly prescribed for COPD. Methods: We performed a retrospective analysis of peripheral blood leucocytes from a previously completed clinical trial that examined effects of ICS in steroid-naive patients with COPD. Results and conclusion: The data show that the ICS-containing treatment arms (containing fluticasone propionate) had a small effect on peripheral blood eosinophils in steroid-naive patients with COPD.

引用

页数：4

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