Effect of inhaled corticosteroids on blood eosinophil count in steroid-naive patients with COPD

被引：39
作者：
Kreindler, James L. [1 ]
Watkins, Michael L. [2 ]
Lettis, Sally [3 ]
Tal-Singer, Ruth [1 ]
Locantore, Nicholas [1 ]
机构：
[1] GlaxoSmithKline Res & Dev Ltd, King Of Prussia, PA USA
[2] GlaxoSmithKline Res & Dev Ltd, Res Triangle Pk, NC USA
[3] GlaxoSmithKline Res & Dev Ltd, Uxbridge, Middx, England
来源：
BMJ OPEN RESPIRATORY RESEARCH | 2016年 / 3卷 / 01期
关键词：
D O I：
10.1136/bmjresp-2016-000151
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Introduction: Sputum and blood eosinophil counts have attracted attention as potential biomarkers in chronic obstructive pulmonary disease (COPD). One question regarding the use of blood eosinophils as a biomarker in COPD is whether their levels are affected by the use of inhaled corticosteroids (ICS), which are commonly prescribed for COPD. Methods: We performed a retrospective analysis of peripheral blood leucocytes from a previously completed clinical trial that examined effects of ICS in steroid-naive patients with COPD. Results and conclusion: The data show that the ICS-containing treatment arms (containing fluticasone propionate) had a small effect on peripheral blood eosinophils in steroid-naive patients with COPD.
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