MPTP TOXICITY IN THE MOUSE-BRAIN AND VITAMIN-E

被引：58

作者：

ODUNZE, IN ^{[1
]}

KLAIDMAN, LK ^{[1
]}

ADAMS, JD ^{[1
]}

机构：

[1] UNIV SO CALIF,SCH PHARM,1985 ZONAL AVE,LOS ANGELES,CA 90033

来源：

NEUROSCIENCE LETTERS | 1990年 / 108卷 / 03期

关键词：

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Oxidative stress; Striatum; Substantia nigra; Vitamin E;

D O I：

10.1016/0304-3940(90)90665-V

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) caused transient alterations in vitamin E levels in every brain region examined. However, vitamin E returned to normal levels within a few hours in all brain regions but the substantia nigra, where at 2 days vitamin E levels first rose above normal levels. Vitamin E deficient mice were much more susceptible to MPTP toxicity than controls, in terms of lethality and DOPAC depletion in the substantia nigra. However, in the same vitamin E deficient mice, the striatum was partially protected from neurotransmitter and metabolite depletion by MPTP. The mechanism of toxicity of MPTP may differ in the striatum and the midbrain. © 1990.

引用

页码：346 / 349

页数：4

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