Effects of renal sympathetic denervation on cardiac systolic function after myocardial infarction in rats

被引:3
作者
Guo, Jiqun [1 ]
Zhou, Zhongxia [1 ]
Li, Zhenzhen [1 ]
Liu, Qian [1 ]
Zhu, Guoqing [2 ]
Shan, Qijun [1 ]
机构
[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanjing 210029, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Physiol Lab, Nanjing 210029, Jiangsu, Peoples R China
来源
JOURNAL OF BIOMEDICAL RESEARCH | 2016年 / 30卷 / 05期
关键词
renal denervation; myocardial infarction; heart failure;
D O I
10.7555/JBR.30.20140164
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
This study investigated the therapeutic effects of renal denervation on cardiac systolic function after myocardial infarction (MI) in rats and the mechanism involved. Fifty male SD rats were randomly assigned to the sham group (n = 15), the MI group (n = 20), and the MI plus renal denervation group (n = 15). MI was established through thoracotomic ligation of the anterior descending artery. Renal denervation was achieved by laparotomic stripping of the renal arterial adventitial sympathetic nerve, approximately 3 mm from the abdominal aorta. Left ventricular function and hemodynamics were measured several weeks following MI. The left ventricular systolic function of the MI group was significantly reduced and the systolic blood pressure (SBP) remarkably declined. In rats with MI treated with renal denervation, the left ventricular ejection fraction (EF), fractional shortening (FS) and SBP markedly improved compared with the MI group. However, heart rate and fibrosis decreased significantly. These findings suggest that renal denervation has therapeutic effects on post-MI cardiac dysfunction. These effects are associated with increased left ventricular ejection fraction (LVEF) and SBP, as well as reduced heart rate and fibrosis. This may represent a new approach to the treatment of post-MI remodeling and subsequent heart failure.
引用
收藏
页码:373 / 379
页数:7
相关论文
共 30 条
  • [1] Anti-beta1-adrenoreceptor autoantibodies and myocardial sympathetic nerve activity in chronic heart failure
    Aso, Shin-ichi
    Yazaki, Yoshikazu
    Kasai, Hiroki
    Takahashi, Masafumi
    Yoshio, Taku
    Yamamoto, Keiji
    Ikeda, Uichi
    [J]. INTERNATIONAL JOURNAL OF CARDIOLOGY, 2009, 131 (02) : 240 - 245
  • [2] Reducing cardiac filling pressure lowers norepinephrine spillover in patients with chronic heart failure
    Azevedo, ER
    Newton, GE
    Floras, JS
    Parker, JD
    [J]. CIRCULATION, 2000, 101 (17) : 2053 - 2059
  • [3] Bohm M, 2010, LANCET, V376, P886, DOI 10.1016/S0140-6736(10)61259-7
  • [4] Renal Sympathetic Denervation Reduces Left Ventricular Hypertrophy and Improves Cardiac Function in Patients With Resistant Hypertension
    Brandt, Mathias C.
    Mahfoud, Felix
    Reda, Sara
    Schirmer, Stephan H.
    Erdmann, Erland
    Boehm, Michael
    Hoppe, Uta C.
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2012, 59 (10) : 901 - 909
  • [5] Vascular Pathophysiology in Response to Increased Heart Rate
    Custodis, Florian
    Schirmer, Stephan H.
    Baumhaekel, Magnus
    Heusch, Gerd
    Boehm, Michael
    Laufs, Ulrich
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2010, 56 (24) : 1973 - 1983
  • [6] Cardiac sympathetic nerve function in congestive heart failure
    Eisenhofer, G
    Friberg, P
    Rundqvist, B
    Quyyumi, AA
    Lambert, G
    Kaye, DM
    Kopin, IJ
    Goldstein, DS
    Esler, MD
    [J]. CIRCULATION, 1996, 93 (09) : 1667 - 1676
  • [7] The sympathetic nervous system through the ages: from Thomas Willis to resistant hypertension
    Esler, Murray
    [J]. EXPERIMENTAL PHYSIOLOGY, 2011, 96 (07) : 1 - 12
  • [8] Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial
    Esler, Murray D.
    Krum, Henry
    Sobotka, Paul A.
    Schlaich, Markus P.
    Schmieder, Roland E.
    Boehm, Michael
    Mahfoud, Felix
    Sievert, Horst
    Wunderlich, Nina
    Rump, Lars Christian
    Vonend, Oliver
    Uder, Michael
    Lobo, Mel
    Caulfield, Mark
    Erglis, Andrejs
    Azizi, Michel
    Sapoval, Marc
    Thambar, Suku
    Persu, Alexandre
    Renkin, Jean
    Schunkert, Heribert
    Weil, Joachim
    Hoppe, Uta C.
    Walton, Tony
    Scheinert, Dierk
    Binder, Thomas
    Januszewicz, Andrzej
    Witkowski, Adam
    Ruilope, Luis M.
    Whitbourn, Robert
    Bruck, Heike
    Downes, Mark
    Luescher, Thomas F.
    Jardine, Alan G.
    Webster, Mark W.
    Zeller, Thomas
    Sadowski, Jerzy
    Bartus, Krzysztof
    Straley, Craig A.
    Barman, Neil C.
    Lee, David P.
    Witteles, Ronald M.
    Bhalla, Vivek
    Massaro, Joseph M.
    [J]. LANCET, 2010, 376 (9756) : 1903 - 1909
  • [9] Progression of heart failure after myocardial infarction in the rat
    Francis, J
    Weiss, RM
    Wei, SG
    Johnson, AK
    Felder, RB
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2001, 281 (05) : R1734 - R1745
  • [10] Goliasch G, 2010, WIEN KLIN WOCHENSCHR, V122, P723, DOI 10.1007/s00508-010-1486-y