ACTIVATION OF PROTEIN-KINASE-C FROM GUINEA-PIG AND RAT VENTRICULAR MUSCLES BY MUSCLIDE-A1 AND ITS (2R,5S)-DIASTEREOMER

被引：6

作者：

KIMURA, I ^{[1
]}

TAKAMURA, Y ^{[1
]}

UWANO, T ^{[1
]}

HATA, Y ^{[1
]}

KIMURA, M ^{[1
]}

KIKUCHI, T ^{[1
]}

机构：

[1] TOYAMA MED & PHARMACEUT UNIV,RES INST WAKAN YAKU ORIENTAL MED,TOYAMA 93001,JAPAN

来源：

PHYTOTHERAPY RESEARCH | 1995年 / 9卷 / 01期

关键词：

VENTRICULAR PROTEIN KINASE C; MUSCLIDE-A1; (2R; 5S)-DIASTEREOMER; 1,2-DIOCTANOYL GLYCEROL;

D O I：

10.1002/ptr.2650090105

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The activating effects of musclide-A1, 6-methyl-2,5-heptanediol 5-(hydrogen sulphate) (la), and its (2R, 5S)- and (2R, SR)-diastereomers on ventricular protein kinase C from guinea-pig and rat were compared with other natural compounds derived from musk and non-natural related compounds, The (2R, 5S)-diastereomer was most potent among musk-derived compounds and its related non-natural compounds. The activation by la (20 mu M) was produced in the presence of low [Ca2+](0) and phosphatidylserine like 1,2-dioctanoylglycerol (2 mu M). The activation pattern for peaks eluted by a hydroxyapatite column demonstrated that la activates ventricular-specific protein kinase C peak II, suggesting one mechanism for the beta-adrenergic cardiotonic potentiation by 1a.

引用

页码：16 / 20

页数：5