CORRELATIONS BETWEEN CHEMICAL-REACTIVITY AND MUTAGENIC ACTIVITY AGAINST SALMONELLA-TYPHIMURIUM TA100 FOR ALPHA-DICARBONYL COMPOUNDS AS A PROOF OF THE MUTAGENIC MECHANISM

被引：0
|
作者：
MELLADO, JMR
MONTOYA, MR
机构：
来源：
MUTATION RESEARCH | 1994年 / 304卷 / 02期
关键词：
AMES TEST; ALPHA-DICARBONYL COMPOUNDS; MECHANISMS OF MUTAGENICITY;
D O I：
暂无
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The mutagenic activities in the Ames test against S. typhimurium TA100 for a series of cr-dicarbonyl compounds are examined together with the formation constants of the adducts formed between such compounds and guanine and guanosine. Correlations between the equilibrium constants, the apparent reaction enthalpies, and the mutagenic activity are presented. These correlations imply that the mutagenic activity is related to the chemical reactivity of the dicarbonyl compounds with the puric bases.
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页码：261 / 264
页数：4
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