1-[(1-Methyl-1H-imidazol-5-yl) methyl]1H-indole-5-carbonitrile

被引：1
作者：
de Jager, Josephus Jacobus [1 ]
Smith, Vincent J. [1 ]
机构：
[1] Stellenbosch Univ, Dept Chem & Polymer Sci, Private Bag X1, ZA-7602 Stellenbosch, South Africa
来源：
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS | 2012年 / 68卷
基金：
新加坡国家研究基金会;
关键词：
data-to-parameter ratio = 20.0; mean ω(C-C) = 0.002 Å; R factor = 0.042; single-crystal X-ray study; T = 100 K; wR factor = 0.113;
D O I：
10.1107/S1600536812048404
中图分类号：
O7 [晶体学];
学科分类号：
0702 ; 070205 ; 0703 ; 080501 ;
摘要：
In the title compound, C14H12N4, the dihedral angle between the indole ring system (r.m.s. deviation = 0.010 angstrom) and the imidazole ring is 77.70 (6)degrees. In the crystal, molecules are linked by C-H center dot center dot center dot N hydrogen bonds. One set of hydrogen bonds forms an undulating chain running parallel to the b-axis direction, while the other undulating chain is parallel to the c-axis direction. In combination, (100) sheets result.
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页码：O3486 / +
页数：7
相关论文
共 8 条
  • [1] Molecular graphics: From science to art
    Atwood, JL
    Barbour, LJ
    [J]. CRYSTAL GROWTH & DESIGN, 2003, 3 (01) : 3 - 8
  • [2] Barbour L.J., 2001, J SUPRAMOL CHEM, V1, P189, DOI DOI 10.1016/S1472-7862(02)00030-8
  • [3] Bruker, 2009, APEX2 SAINT SADABS
  • [4] 2-oxotetrahydroquinoline-based antimalarials with high potency and metabolic stability
    Bulbule, Vivek J.
    Rivas, Kasey
    Verlinde, Christophe L. M. J.
    Van Voorhis, Wesley C.
    Gelb, Michael H.
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (03) : 384 - 387
  • [5] Protein farnesyltransferase and protein prenylation in Plasmodium falciparum
    Chakrabarti, D
    Da Silva, T
    Barger, J
    Paquette, S
    Patel, H
    Patterson, S
    Allen, CM
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (44) : 42066 - 42073
  • [6] de Ruyck J, 2008, CURR PROTEIN PEPT SC, V9, P117
  • [7] A short history of SHELX
    Sheldrick, George M.
    [J]. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2008, 64 : 112 - 122
  • [8] Efficacy, pharmacokinetics, and metabolism of tetrahydroquinoline inhibitors of Plasmodium falciparum protein farnesyltransferase
    Van Voorhis, Wesley C.
    Rivas, Kasey L.
    Bendale, Pravin
    Nallan, Laxman
    Horney, Carolyn
    Barrett, Lynn K.
    Bauer, Kevin D.
    Smart, Brian P.
    Ankala, Sudha
    Hucke, Oliver
    Verlinde, Christophe L. M. J.
    Chakrabarti, Debopam
    Strickland, Corey
    Yokoyama, Kohei
    Buckner, Frederick S.
    Hamilton, Andrew D.
    Williams, David K.
    Lombardo, Louis J.
    Floyd, David
    Gelb, Michael H.
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2007, 51 (10) : 3659 - 3671
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