SYNTHESIS AND ANTIMICROBIAL EVALUATION OF NOVEL OXA(THIA)DIAZOLYLQUINOLINES AND OXA(THIA)DIAZEPINO[7,6-B] QUINOLINES

被引：45

作者：

KHALIL, MA ^{[1
]}

ELSAYED, OA ^{[1
]}

ELSHAMY, HA ^{[1
]}

机构：

[1] UNIV ALEXANDRIA,HIGH INST PUBL HLTH,DEPT MICROBIOL,ALEXANDRIA,EGYPT

来源：

ARCHIV DER PHARMAZIE | 1993年 / 326卷 / 08期

关键词：

D O I：

10.1002/ardp.19933260812

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three novel series of quinoline derivatives have been prepared by cyclization of the intermediate 3[(substituted)thiocarbamoyl-hydrazonomethyl]-2-chloroquinolines and 3-aroylhydrazonomethyl-2-chloroquinolines: 3-(3-Acetyl-5-(substituted)-2,3-dihydro-1,3,4-oxa(thia)diazol-2-yl)-2-chloroquinolines (4; 5), 3-(5-(substituted)-1,3,4-oxa(thia)diazol-2-yl)-2-chloroquinolines (6; 7), and 2-(substituted)-1,3,4-oxa(thia)diazepino[7,6-b]quinolines (8; 9). The antimicrobial activity of these compounds was studied.

引用

页码：489 / 492

页数：4

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