ESTIMATION OF MYOCARDIAL WATER-CONTENT USING TRANSVERSE RELAXATION-TIME FROM DUAL SPIN-ECHO MAGNETIC-RESONANCE-IMAGING

被引：40
作者：
BOXT, LM
HSU, D
KATZ, J
DETWEILER, P
MCLAUGHLIN, S
KOLB, TJ
SPOTNITZ, HM
机构：
[1] Department of Radiology, College of Physicians and Surgeons, Columbia University, New York
[2] Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York
[3] Department of Medicine (Cardiology), College of Physicians and Surgeons, Columbia University, New York
[4] Department of Surgery, College of Physicians and Surgeons, Columbia University, New York
来源：
MAGNETIC RESONANCE IMAGING | 1993年 / 11卷 / 03期
关键词：
MRI; MYOCARDIAL EDEMA; TRANSVERSE RELAXATION;
D O I：
10.1016/0730-725X(93)90070-T
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Dual spin-echo magnetic resonance imaging may be used f or calculation of transverse myocardial relaxation time from the signal intensity of the echoes considered. In this study, the ability of myocardial transverse relaxation time (T2) to quantitate myocardial edema of the right ventricle (RV) and left ventricle (LV) was tested. Dual spin-echo magnetic resonance images of the entire hearts were obtained and T2 of the RV and LV myocardium calculated from the signal intensities within multiple regions of interest distributed over the myocardium. Six hearts were intermittently perfused through an aortic cannula with three perfusates of decreasing osmolality. Biopsies were obtained for water content (WC) analysis both before and after imaging the hearts at baseline and postperfusion. A seventh (control) heart was not perfused; instead dual spin-echo imaging was performed at the same time intervals as in the perfused hearts. Prior to any intervention, there was no significant difference between baseline RV (79.49 +/- 2.10%) and LV (77.99 +/- 2.44%, p = .2) myocardial water content; RV myocardial T2 (59.9 +/- 5.8 msec) was slightly but not significantly longer than that of the LV (54.6 +/- 5.7 msec, p = .1). After induction of edema, strong correlation was found between right ventricular myocardial water content measurements and right ventricular T2 (RV WC = 68.5 + 0.19 x RV T2; N = 27, R = 0.92, p < .0001, SEE = 1.56%). Similarly, strong correlation was found between left ventricular myocardial water content and T2 (LV WC = 62.1 + 0.29 x LV T2; N = 27, R = 0.92, p < .0001, SEE = 1.80%). However, slopes of these two regression lines were significantly different (p < .01). Thus, we conclude that myocardial T2 may be used to quantitate regional myocardial edema. Differences in the relationship between RV and LV myocardial water content and their effect on T2 may represent differences in the manner each tissue distributes edema fluid.
引用
收藏
页码：375 / 383
页数：9
相关论文
共 24 条
[1]  
Foglia, Lazar, Steed, Et al., Iatrogenic myocardial edema with crystalloid primes: Effects on left ventricular compliance, performance, and perfusion, Surg. Forum, 29, (1978)
[2]  
Salisbury, Cross, Rieben, Distensibility and water content of heart muscle before and after injury, Circulation Research, 8, pp. 788-793, (1960)
[3]  
Cross, Rieben, Salisbury, Influence of coronary perfusion and myocardial edema on pressure-volume diagram of left ventricle, Am J Physiol, 201, pp. 102-108, (1961)
[4]  
Jennings, Ganote, Reimer, Ischemic tissue injury, Am. J. Pathol., 81, pp. 179-198, (1975)
[5]  
Whalen, Hamilton, Ganote, Jennings, Effect of a transient period of ischemia on myocardial cells, Am. J. Pathol., 74, pp. 381-398, (1974)
[6]  
Willerson, Watson, Hutton, Templeton, Fixler, Reduced myocardial reflow and increased coronary vascular resistance following prolonged myocardial ischemia in the dog, Cir. Res., 36, pp. 771-781, (1975)
[7]  
Sasaguri, Sunamori, Saito, Suzuki, Early change of myocardial water during acute cardiac allograft rejection, Japanese Circulation Journal, 50, pp. 1113-1119, (1986)
[8]  
Laks, Standeven, Blair, Hahn, Jellinek, Willman, The effects of cardiopulmonary bypass with crystalloid and colloid hemodilution on myocardial extravascular water, J. Thorac. Cardiovasc. Surg., 73, pp. 129-138, (1977)
[9]  
Haasler, Rodigas, Collins, Et al., Two-dimensional echocardiography in dogs. Variation of left ventricular mass, geometry, volume, and ejection fraction on cardiopulmonary bypass, J. Thorac. Cardiovasc. Surg., 90, pp. 430-440, (1985)
[10]  
Ortendahl, Hylton, Kaufman, Watts, Crooks, Mills, Stark, Analytic tools for magnetic resonance imaging, Radiology, 153, pp. 479-488, (1984)
123