MODULATION OF NEUROEFFECTOR TRANSMISSION IN THE GUINEA-PIG PULMONARY-ARTERY BY ENDOGENOUS NITRIC-OXIDE

被引：39
作者：
CEDERQVIST, B
WIKLUND, NP
PERSSON, MG
GUSTAFSSON, LE
机构：
[1] KAROLINSKA INST, KAROLINSKA HOSP, DEPT UROL, S-10401 STOCKHOLM 60, SWEDEN
[2] KAROLINSKA INST, KAROLINSKA HOSP, INST ENVIRONM MED, S-10401 STOCKHOLM 60, SWEDEN
来源：
NEUROSCIENCE LETTERS | 1991年 / 127卷 / 01期
关键词：
EDRF; NITRIC OXIDE; NG-MONOMETHYL-L-ARGININE; NORADRENALINE RELEASE; NONADRENERGIC-NONCHOLINERGIC NEUROTRANSMISSION; SMOOTH MUSCLE;
D O I：
10.1016/0304-3940(91)90896-2
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The influence of endogenous nitric oxide (NO) on neuroeffector transmission in segments of guinea pig pulmonary artery was analyzed by application of N(G)-monomethyl-L-arginine (L-NMMA). L-NMMA enhanced contractile responses to nerve stimulation and this enhancement was counteracted by L-arginine. The enhancement remained after removal of the endothelium. L-NMMA enhanced contractions to exogenous noradrenaline. After blockade of adrenergic transmission by phentolamine, L-NMMA enhanced contractions induced by nonadrenergic-noncholinergic (NANC) neurotransmission. Stimulation-induced release of [H-3]noradrenaline was unchanged by L-NMMA. The results suggest that endogenous NO exerts a postjunctional inhibition on adrenergic neurotransmission in the guinea pig pulmonary artery. A concomitant pre- and/or postjunctional inhibition of NANC transmission is implicated. The neuromodulation by NO does not require an intact endothelium.
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收藏
页码：67 / 69
页数：3
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