MUCOSAL IMMUNITY FOLLOWING ORAL POLIOVIRUS VACCINE AND ENHANCED POTENCY INACTIVATED POLIOVIRUS VACCINE IMMUNIZATION

被引：13

作者：

MODLIN, JF

机构：

[1] Disease Section, Dartmouth Hitchcock Medical Center, Hanover, NH

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 1991年 / 10卷 / 12期

关键词：

MUCOSAL IMMUNITY POLIOVIRUS; ORAL POLIO VIRUS VACCINE; INACTIVATED POLIOVIRUS VACCINE;

D O I：

10.1097/00006454-199112000-00031

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mucosal immunity is considered to be an important barrier for inhibiting person-to-person transmission of naturally occurring (wild type) poliovirus infection. This review briefly summarizes the results of a previously published study in which 79 oral poliovirus vaccine (OPV) vaccinated children and 93 enhanced-potency inactivated poliovirus vaccine (IPV) children were challenged with one of two doses of type 1 OPV virus to test the oropharyngeal and gastrointestinal mucosal immunity conferred by each type of poliovirus vaccine. Although both OPV and IPV produced excellent oropharyngeal immunity, OPV was clearly superior in decreasing fecal shedding of the challenge virus.

引用

页码：976 / 978

页数：3

共 13 条

[1]

FOX JP, 1984, REV INFECT DIS, V6, pS352

[2] QUANTITATIVE RELATIONSHIP OF PREEXISTING HOMOTYPIC ANTIBODIES TO EXCRETION OF ATTENUATED POLIOVIRUS TYPE 1 [J].