NEGATIVE REGULATION OF CD45 PROTEIN TYROSINE PHOSPHATASE-ACTIVITY BY IONOMYCIN IN T-CELLS

被引：109

作者：

OSTERGAARD, HL ^{[1
]}

TROWBRIDGE, IS ^{[1
]}

机构：

[1] SALK INST,DEPT CANC BIOL,SAN DIEGO,CA 92186

来源：

SCIENCE | 1991年 / 253卷 / 5026期

关键词：

D O I：

10.1126/science.1654595

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

CD45 is a leukocyte-specific, transmembrane protein tyrosine phosphatase (PTPase) required for T cell responsiveness. How the activity of PTPases is regulated in vivo is unclear. Treatment of murine thymocytes and a variety of murine T cell lines with the calcium ionophore ionomycin decreased CD45 PTPase activity. Ionomycin treatment also led to a decreased phosphorylation of serine residues in CD45. These results indicate that increased intracellular calcium modulates CD45 PTPase activity, demonstrating regulation of CD45 PTPase activity in vivo, and also implicate serine dephosphorylation as a possible mechanism.

引用

页码：1423 / 1425

页数：3

共 30 条

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