Synthesis, Characterization and Antioxidant Studies of Quinazolin Derivatives

被引：3

作者：

Al-Azawi, Khalida ^{[1
]}

机构：

[1] Univ Technol Baghdad, Dept Chem, Coll Sci, Baghdad, Iraq

来源：

ORIENTAL JOURNAL OF CHEMISTRY | 2016年 / 32卷 / 01期

关键词：

Antioxidant activity; Avenging activities; 1,1-diphenyl-2-picrylhydrazyl; Nitric oxide;

D O I：

10.13005/ojc/320166

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

3-((4-(dimethylamino)benzylidene)amino)-2-methylquinazolin-4(3H)-one (3), 3-((4-hydroxybenzylidene)amino)-2-methylquinazolin-4(3H)-one (4), 2-methyl-3-(pyrrolidin-2-ylideneamino)quinazolin-4(3H)-one (5) and 3,3'-((1,4-phenylenebis(methanylylidene)) bis(azanylylidene) bis(2-methylquinazolin-4(3H)-one) (6) derived from 3-amino-2-methylquinazolin-4(3H)-one have been synthesized and characterized by elemental analysis, FT-IR, NMR techniques and screened to establish their potential as antioxidants against 1,1-diphenyl-2-picrylhydrazyl (DPPH) and Nitric oxide (NO) radical scavengers. The results revealed that synthesized compounds (5 and 6) are much higher than common antioxidants ascorbic acid and they showed excellent scavenging capacity against DPPH and Nitric oxide (NO). The synthesized compounds (3 and 4) demonstrated encouraging results comparable with ascorbic acid.

引用

页码：585 / 590

页数：6

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