SYNTHESIS OF SQUALAMINE - A STEROIDAL ANTIBIOTIC FROM THE SHARK

被引：59

作者：

MORIARTY, RM ^{[1
]}

TULADHAR, SM ^{[1
]}

GUO, L ^{[1
]}

WEHRLI, S ^{[1
]}

机构：

[1] UNIV PENN,CHILDRENS HOSP PHILADELPHIA,PHILADELPHIA,PA 19104

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 44期

关键词：

D O I：

10.1016/0040-4039(94)88254-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The title compound was synthesized from 3 beta-acetoxy-5-cholenic acid (2) in 17 steps.

引用

页码：8103 / 8106

页数：4

共 17 条

[1] ARNOSTOVA LM, 1990, SYNTHETIC COMMUN, V20, P1521
[2] THE TRIISOPROPYLSILYL GROUP AS A HYDROXYL-PROTECTING FUNCTION
CUNICO, RF
BEDELL, L
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1980, 45 (23) : 4797 - 4798
[3] POLYENE ANTIBIOTIC-STEROL INTERACTIONS IN MEMBRANES OF ACHOLEPLASMA-LAIDLAWII CELLS AND LECITHIN LIPOSOMES .3. MOLECULAR-STRUCTURE OF POLYENE ANTIBIOTIC-CHOLESTEROL COMPLEXES
DEKRUIJFF, B
DEMEL, RA
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1974, 339 (01) : 57 - 70
[4] DJERASSI C, 1951, ORG REACTIONS, V6, P207
[5] STEREOCHEMISTRY OF THE 1,2,3,4-DIBENZ-1,3-CYCLOOCTADIENE SYSTEM
DVORKEN, LV
SMYTH, RB
MISLOW, K
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1958, 80 (02) : 486 - 492
[6] A METHOD OF SYNTHESIS OF ALLOCHOLANOIC ACIDS - BILE ACIDS AND STEROIDS 182
KALLNER, A
[J]. ACTA CHEMICA SCANDINAVICA, 1967, 21 (02): : 322 - &
[7] LEVAI L, 1960, BER, V93, P387
[8] SQUALAMINE - AN AMINOSTEROL ANTIBIOTIC FROM THE SHARK
MOORE, KS
WEHRLI, S
RODER, H
ROGERS, M
FORREST, JN
MCCRIMMON, D
ZASLOFF, M
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (04) : 1354 - 1358
[9] SYNTHETIC STUDIES OF VITAMIN-D3 ANALOGS FROM BILE-ACIDS .2. SYNTHESES OF CHOLESTA-1,4-DIEN-3-ONES AND CHOLESTA-1,4,6-TRIEN-3-ONES HAVING A 24-HYDROXYLATED AND-OR 25-HYDROXYLATED SIDE-CHAIN FROM LITHOCHOLIC ACID
OCHI, K
MATSUNAGA, I
SHINDO, M
KANEKO, C
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1979, (01): : 161 - 164
[10] A NEW METHOD FOR THE OXIDATION OF ALKENES TO ENONES - AN EFFICIENT SYNTHESIS OF DELTA-5-7-OXO STEROIDS
PEARSON, AJ
CHEN, YS
HAN, GR
HSU, SY
RAY, T
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1985, (02): : 267 - 273

← 1 2 →