IMPLICATIONS OF A NONLAMELLAR LIPID PHASE FOR THE TIGHT JUNCTION STABILITY .2. REVERSIBLE MODULATION OF TRANSEPITHELIAL RESISTANCE IN HIGH AND LOW RESISTANCE MDCK-CELLS BY BASIC-AMINO-ACIDS, CA-2+, PROTAMINE AND PROTONS

被引：17

作者：

HEIN, M ^{[1
]}

MADEFESSEL, C ^{[1
]}

HAAG, B ^{[1
]}

TEICHMANN, K ^{[1
]}

POST, A ^{[1
]}

GALLA, HJ ^{[1
]}

机构：

[1] UNIV MUNSTER,INST BIOCHEM,WILHELM KLEMM STR 2,W-4400 MUNSTER,GERMANY

来源：

CHEMISTRY AND PHYSICS OF LIPIDS | 1992年 / 63卷 / 03期

关键词：

EPITHELIAL CELLS; TIGHT JUNCTIONS; RESISTANCE; NON-LAMELLAR LIPID PHASE;

D O I：

10.1016/0009-3084(92)90038-Q

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The transepithelial resistance of confluent epithelial cell monolayers was monitored to investigate the influence of basic amino acids, Ca2+, protamine and protons on tight junction electrical resistance. In an accompanying paper we investigated the effect of these substances on the lamellar/hexagonal II phase transition in reconstituted phospholipid membranes containing phosphatidylserine and phosphatidylethanolamine. We conclude that the permeability of tight junctions may be described by a lipid phase equilibrium where the lamellar phase corresponds to an open state and the hexagonal lipid phase to the closed state of the cell contact. This dynamic lipid model is well suited to describe the morphological as well as functional properties of the tight junctions.

引用

页码：223 / 233

页数：11

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