SUBTYPE OF THE MUSCARINIC RECEPTOR THAT MEDIATES SALIVARY SECRETION IN THE RAT SUBLINGUAL GLAND

被引:0
|
作者
IWABUCHI, Y
MASUHARA, T
机构
来源
ASIA PACIFIC JOURNAL OF PHARMACOLOGY | 1992年 / 7卷 / 03期
关键词
SUBLINGUAL GLAND; SALIVATION; MUSCARINIC RECEPTOR; CARBACHOL; MCN-A-343;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The subtype of the muscarinic receptor that mediates salivary secretion in the rat sublingual gland was characterized by use of agonists, carbachol (CAR) and McN-A-343, and antagonists of various types. CAR elicited a long-lasting flow of saliva, and the rate of secretion increased in a dose-dependent manner. By contrast, McN-A-343 did not elicit any significant salivation even at doses as high as 1 mg kg-1. When an antagonist at a dose of 1 mg kg-1 was-injected i.v. 30 min prior to administration of CAR at a dose of 30 mug kg-1, the dose that inhibited, by 50% the sialogogic action of CAR, was 1.9 mug kg-1 for atropine, 4.1 mug kg-1 for 4-DAMP and 205 mug kg-1 for pirenzepine. However, pretreatment with AF-DX-116, phentolamine, propranolol or hexamethonium at a dose of 1 mg kg-1 did not have any significant inhibitory effect. The results suggest that the muscarinic receptors that mediate secretion of saliva from the rat sublingual gland are of the M3 subtype.
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页码:197 / 202
页数:6
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