EFFECTS OF ANTIMICROTUBULE AGENTS ON CELL MOTILITY IN FIBROBLAST AGGREGATES

被引：8

作者：

ARMSTRONG, MT

ARMSTRONG, PB

机构：

[1] Department of Zoology, University of California, Davis

来源：

EXPERIMENTAL CELL RESEARCH | 1979年 / 120卷 / 02期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/0014-4827(79)90395-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Spherical aggregates of chick heart, sclera and skin fibroblasts were fused with tritiated thymidine-labelled aggregates of the identical cell type. After being placed in contact, the two aggregates cohered and broadened the area of contact to form a single aggregate with a planar interface between the labelled and unlabelled halves. The motility of cells in the aggregate was determined by measuring the movement of labelled cells across the boundary into the unlabelled half. Exposure to pharmacological doses of antimicrotubule agents resulted in a significant reduction in fibroblast motility in the three-dimensional aggregates. © 1979.

引用

页码：359 / 364

页数：6

共 28 条

[1]

ABERCROMBIE M., 1961, EXPTL CELL RES SUPPL, V8, P188, DOI 10.1016/0014-4827(61)90348-2

[2]

ABERCROMBIE M, 1973, CIBA F S CELL MOTILI

[3]

AMBROSE E. J., 1961, EXPTL CELL RES SUPPL, V8, P54, DOI 10.1016/0014-4827(61)90340-8

[4]

ARMSTRONG MT, 1978, J CELL SCI, V33, P37