EARLY ENHANCEMENT OF CALCIUM CURRENTS BY H-RAS ONCOPROTEINS INJECTED INTO HERMISSENDA NEURONS

被引：53

作者：

COLLIN, C ^{[1
]}

PAPAGEORGE, AG ^{[1
]}

LOWY, DR ^{[1
]}

ALKON, DL ^{[1
]}

机构：

[1] NCI, CELLULAR ONCOL LAB, FREDERICK, MD 21701 USA

来源：

SCIENCE | 1990年 / 250卷 / 4988期

关键词：

D O I：

10.1126/science.2176747

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Influx of calcium through membrane channels is an important initial step in signal transduction of growth signals. Therefore, the effects of Ras protein injection on calcium currents across the soma membrane of an identified neuron of the snail Hermissenda were examined. With the use of these post-mitotic cells, a voltage-sensitive, inward calcium current was increased 10 to 20 minutes after Harvey-ras oncoproteins were injected. The effects of oncogenic Harvey rat p21 protein (v-Ras) occurred quickly and were sustained, whereas the effects of proto-oncogenic ras protein (c-Ras) were transient. This relative potency is consistent with the activities of these oncoproteins in stimulating cell proliferation. Thus, this calcium channel may be a target for Ras action.

引用

页码：1743 / 1745

页数：3

共 35 条

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