HYDROLYSIS OF SYNTHETIC CHROMOGENIC SUBSTRATES BY HIV-1 AND HIV-2 PROTEINASES

被引：64
作者：
PHYLIP, LH
RICHARDS, AD
KAY, J
KONVALINKA, J
STROP, P
BLAHA, I
VELEK, J
KOSTKA, V
RITCHIE, AJ
BROADHURST, AV
FARMERIE, WG
SCARBOROUGH, PE
DUNN, BM
机构：
[1] UNIV COLL CARDIFF, DEPT BIOCHEM, POB 903, CARDIFF CF1 1ST, WALES
[2] CZECHOSLOVAK ACAD SCI, INST ORGAN CHEM & BIOCHEM, FLEMINGOVO NAMESTI 2, CS-16610 PRAGUE 6, CZECHOSLOVAKIA
[3] ROCHE PROD LTD, WELWYN GARDEN CITY AL7 3AY, HERTS, ENGLAND
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 171卷 / 01期
关键词：
D O I：
10.1016/0006-291X(90)91412-L
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Kinetic constants (Km,kcat) are derived for the hydrolysis of a number of chromogenic peptide substrates by the aspartic proteinase from HIV-2. The effect of systematic replacement of the P2 residue on substrate hydrolysis by HIV-1 and HIV-2 proteinases is examined. © 1990.
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页码：439 / 444
页数：6
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