AUTOIMMUNE THROMBOCYTOPENIC PURPURA COMPLICATING LYMPHOPROLIFERATIVE DISORDERS

被引:15
作者
LIM, SH
IFTHIKHARUDDIN, JJ
机构
[1] Department of Haematology, University of Wales College of Medicine, Heath Park, Cardiff
关键词
AUTOIMMUNE THROMBOCYTOPENIA PURPURA; LYMPHOPROLIFERATIVE DISORDERS;
D O I
10.3109/10428199409051678
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Thrombocytopenia in patients with lymphoproliferative disorders is usually multifactorial. In some patients, peripheral destruction of platelets by platelet autoantibodies may account in part for the thrombocytopenia. However, the diagnosis of autoimmune thrombocytopenic pur pura in this group of patients can be difficult due to the splenomegaly and compromised bone marrows in some of these patients. The development of autoimmune thrombocytopenic purpura in these patients does not affect the eventual outcome of the underlying lymphoproliferative disorders. Unfortunately the current available therapy for this condition is unsatisfactory. Other innovative treatment modalities are therefore much needed.
引用
收藏
页码:61 / 64
页数:4
相关论文
共 20 条
[1]  
Hegde U.M., Zuiable A., Ball S., Roter B.L.T., The relative incidence of idiopathic and secondary autoimmune thrombocytopenia: A clinical and serological evaluation in 508 patients, Clin. Lab. Haematol., 7, pp. 7-16, (1985)
[2]  
Helmerhorst F.M., van Leeuwen E.F., Pegels J.G., van-der Plas-van Dalen C., Eengelfriet C.P., von Dem Bome Kr A.E.G., Primary and secondary autoimmune thrombocytopenia: A serological and clinical analysis, Stand. J. Haematol., 28, pp. 319-328, (1982)
[3]  
Jones S.E., Autoimmune disorders and malignant lymphoma, Cancer, 31, pp. 1092-1098, (1973)
[4]  
Rudders R.A., Aisenberg A.C., Schiller A.L., Hodgkin's disease presenting as “Idiopathic” thrombocytopenic purpura, Cancer, 30, pp. 220-230, (1972)
[5]  
Fink K., Al-Mondhiry H., Idiopathic thrombocytopenic purpura in lymphoma, Cancer, 37, pp. 1999-2004, (1976)
[6]  
Rubenstein D.B., Longo D.L., Peripheral destruction of platelets in chronic lymphocytic leukemia: Recognition, prognosis and therapeutic implications, Am. J. Med., 71, pp. 729-732, (1981)
[7]  
Kaden B.R., Rosse W.F., Hauch T.W., Immune thrombocytopenia in lymphoproliferative diseases, Blood, 53, pp. 545-555, (1979)
[8]  
Wadell C.C., Cimo P.L., Idiopathic thrombocytopenic purpura occuring in Hodgkin's disease after splenectomy: Report of two cases and review of the literature, Am. J. Hematol., 7, pp. 381-387, (1979)
[9]  
Jackson S.R., Carter J.M., Platelet volume: Laboratory measurement and clinical application, Blood Rev., 7, pp. 104-113, (1993)
[10]  
Kiefel V., Becker T., Mueller-Eckhardt G., Platelet survival determined with 51Cr versus 111, Klin. Wochenschr., 63, pp. 84-89, (1985)