EFFECTS OF THE CONVENTIONAL ANTICONVULSANTS, PHENYTOIN, CARBAMAZEPINE, AND VALPROIC ACID, ON SODIUM-POTASSIUM-ADENOSINE TRIPHOSPHATASE IN ACUTE ISCHEMIC BRAIN

被引：23

作者：

MURAKAMI, A ^{[1
]}

FURUI, T ^{[1
]}

机构：

[1] AICHI MED UNIV, DEPT NEUROSURG, NAGAKUTE, AICHI 48011, JAPAN

来源：

NEUROSURGERY | 1994年 / 34卷 / 06期

关键词：

CARBAMAZEPINE; CEREBRAL ISCHEMIA; PHENYTOIN; SODIUM-POTASSIUM-ADENOSINE TRIPHOSPHATASE; VALPROIC ACID;

D O I：

10.1227/00006123-199406000-00014

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

THE EFFECTS OF phenytoin, carbamazepine and valproic acid on alterations in sodium-potassium-adenosine triphosphatase activity during ischemia were studied in the rat brain. Pretreatment with phenytoin and carbamazepine prevented a reduction of this activity, which, without either treatment, was observed in the cerebral hemisphere exposed to 30-minute ischemia resulting from unilateral middle cerebral artery occlusion. Valproic acid, on the other hand, did not principally affect the ischemic impairment of this membrane-bound enzyme activity. These results lend support to the previously proposed use of phenytoin in cerebral ischemia, but also suggest the therapeutic availability of another common anticonvulsant, carbamazepine, for treatment of the insult.

引用

页码：1047 / 1051

页数：5

共 36 条

[1] EFFECT OF PRETREATMENT WITH THIOPENTAL AND PHENYTOIN ON POST-ISCHEMIC BRAIN-DAMAGE IN RABBITS [J].

ALDRETE, JA ;

ROMOSALAS, F ;

JANKOVSKY, L ;

FRANATOVIC, Y .

CRITICAL CARE MEDICINE, 1979, 7 (10) :466-470

[2] CEREBRAL PROTECTIVE, METABOLIC, AND VASCULAR EFFECTS OF PHENYTOIN [J].

ARTRU, AA ;

MICHENFELDER, JD .

STROKE, 1980, 11 (04) :377-382

[3] ENERGY-REQUIRING CELL FUNCTIONS IN THE ISCHEMIC BRAIN - THEIR CRITICAL SUPPLY AND POSSIBLE INHIBITION IN PROTECTIVE THERAPY [J].

ASTRUP, J .

JOURNAL OF NEUROSURGERY, 1982, 56 (04) :482-497

[4] ISCHEMIC CEREBRAL EDEMA IN PRIMATES - EFFECTS OF ACETAZOLAMIDE, PHENYTOIN, SORBITOL, DEXAMETHASONE, AND METHYLPREDNISOLONE ON BRAIN WATER AND ELECTROLYTES [J].

BREMER, AM ;

YAMADA, K ;

WEST, CR .

NEUROSURGERY, 1980, 6 (02) :149-154

[5]

CRANE P, 1970, NEUROLOGY, V20, P1119

[6]

CULLEN JP, 1979, ANESTH ANALG, V58, P165

[7] ROLE OR NON-ROLE OF ATPASE ACTIVATION BY PHENYTOIN IN STABILIZATION OF EXCITABLE MEMBRANES [J].

DEUPREE, JD .

EPILEPSIA, 1977, 18 (03) :309-315

[8] EFFECT OF DIPHENYLHYDANTOIN ON SYNAPTOSOME SODIUM-POTASSIUM-ATPASE [J].

FESTOFF, BW ;

APPEL, SH .

JOURNAL OF CLINICAL INVESTIGATION, 1968, 47 (12) :2752-&

[9]

Fiske CH, 1925, J BIOL CHEM, V66, P375

[10] IN-VIVO AND IN-VITRO EFFECT OF DIPHENYLHYDANTOIN AND PHENOBARBITONE ON K+-ACTIVATED PHOSPHOHYDROLASE AND (NA+, K+)-ACTIVATED ATPASE IN PARTICULATE MEMBRANE FRACTIONS FROM RAT BRAIN [J].

FORMBY, B .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1970, 22 (02) :81-&

← 1 2 3 4 →